Importance: There are over 3,500 homeless individuals in Miami-Dade County with over 1,000 of them being unsheltered at any given time. The Miami Street Medicine (MSM) team was founded by medical students in partnership with the Dade County Street Response (DCSR) and conducts medical outreach for persons experiencing homelessness (PEH), including a substantial amount of wound care. The wounds that these patients suffer from exist in the unique setting of homelessness and often other comorbidities including IV drug use, HIV/HCV infection, and chronic diseases such as diabetes, autoimmune disorders, and mental health conditions. As a result, PEH with chronic wounds require specialized care that may not follow protocols used in a clinic setting. Objective: Given the paucity of data about wound care in this underserved population, the primary objective of this study is to investigate the epidemiology of wounds in PEH seen by the MSM clinic. In addition, this project will aim to provide an example of a health care delivery model that addresses the wound care needs of PEH and provide specific recommendations for wound care in this population who otherwise might not receive treatment. Methods: A retrospective chart review of street runs from April 10th, 2021 to January 22nd, 2022 was conducted using existing MSM electronic health records. Key words such as “wound,” “ulcer,” “abscess,” “lesion,” “abrasion,” “incision,” “erosion,” “blister,” “fung*,” “necro*,” “dress*,” and “bandage” were used to search records. Charts where wounds and skin infections were seen were included and data on wound care performed was abstracted. Results: In the study period, 40 mobile street clinics were conducted in the Miami Medical district. There were 145 distinct unsheltered patients documented in the RedCap electronic medical record used on the street runs. Among these, 21 patients presented with a wound complaint, with an average age of 55 Â± 0.77 years old. Four (19%) patients identified as white non-Hispanic, 10 (48%) as white Hispanic, and seven (33%) as black African American. 76% of patients received some level of wound care from the MSM team, including but not limited to saline washing and dressing changes, mechanical debridement, providing antibiotics on site and prescriptions, and topical antifungals and corticosteroids. In total, approximately 251 patients were seen over the study period, with 52 encounters of wound care (21%). On average, there was at least one instance per street run. Conclusion: Currently, mainstream health care systems are falling short to meet the multifaceted needs of the vulnerable unsheltered homeless population in a socially just manner. Weekly street runs by the MSM team demonstrate wound care is significant health need in the unsheltered homeless community and this clinic can serve as a model of care in a major urban city to provide wound care in those who may not receive care otherwise.